The significance of renal C4d staining in patients with BK viruria, viremia, and nephropathy
نویسندگان
چکیده
منابع مشابه
A Case of BK Nephropathy without Detectable Viremia or Viruria
BACKGROUND BK nephropathy is an evolving challenge among kidney transplant recipients. Diagnosis of BK nephropathy depends on the presence of BK viral inclusions on renal biopsy. Most cases of BK nephropathy are preceded by BK viremia or viruria. CASE REPORT We report a case of BK nephropathy found on protocol renal transplant biopsy without associated BK viremia or viruria. CONCLUSIONS BK ...
متن کاملBK-virus nephropathy and simultaneous C4d positive staining in renal allografts.
The role of antibodies in rejection of transplanted kidneys was the subject of debate at the last two Banff meetings and in medical journals. Diffuse C4d positive staining of peritubular capillaries (PTCs) was recognized as a marker of antibody-mediated rejection and this morphological feature was included in the updated Banff schema. At the same time polyomavirus infection of the renal allogra...
متن کاملBK viruria and viremia in children with systemic lupus erythematosus
BACKGROUND BK virus (BKV) is a ubiquitous polyoma virus that lies dormant in the genitourinary tract once acquired in early childhood. In states of cellular immunodeficiency, the virus can reactivate to cause hemorrhagic cystitis and nephritis. Children with systemic lupus erythematosus (SLE) have an increased risk of developing infectious complications secondary to their immunocompromised stat...
متن کاملBK Viremia among Iranian Renal Transplant Candidates
Background: Primary infection with BK virus (BKV) is occurred during childhood and usually asymptomatic, but after initial infection, BKV may persist lifelong in the kidney and genitourinary tract. Reactivation may occur in individuals with compromised immunity such as renal transplant recipients. Due to the role of BKV in BK virus-associated nephropathy (BKVAN) and po...
متن کاملHigh-level viruria as a screening tool for BK virus nephropathy in renal transplant recipients
BACKGROUND Although early monitoring of BK virus infection in renal transplant patients has led to improved outcomes over the past decade, it remains unclear whether monitoring for viremia is the best screening tool for BK virus nephropathy (BKVN). METHODS We conducted a retrospective review of the medical records of 368 renal transplant recipients who had a minimum of 18 months of posttransp...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2009
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.2009.118